Host immune cellular reactions in corneal neovascularization
Identifieur interne : 001004 ( Main/Exploration ); précédent : 001003; suivant : 001005Host immune cellular reactions in corneal neovascularization
Auteurs : Nizar S. Abdelfattah [États-Unis] ; Mohamed Amgad [Égypte] ; Amira A. Zayed [États-Unis]Source :
- International Journal of Ophthalmology [ 2222-3959 ] ; 2016.
Abstract
Corneal neovascularization (CNV) is a global important cause of visual impairment. The immune mechanisms leading to corneal heme- and lymphangiogenesis have been extensively studied over the past years as more attempts were made to develop better prophylactic and therapeutic measures. This article aims to discuss immune cells of particular relevance to CNV, with a focus on macrophages, Th17 cells, dendritic cells and the underlying immunology of common pathologies involving neovascularization of the cornea. Hopefully, a thorough understanding of these topics would propel the efforts to halt the detrimental effects of CNV.
Url:
DOI: 10.18240/ijo.2016.04.25
PubMed: 27162740
PubMed Central: 4853363
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Corneal neovascularization (CNV) is a global important cause of visual impairment. The immune mechanisms leading to corneal heme- and lymphangiogenesis have been extensively studied over the past years as more attempts were made to develop better prophylactic and therapeutic measures. This article aims to discuss immune cells of particular relevance to CNV, with a focus on macrophages, Th17 cells, dendritic cells and the underlying immunology of common pathologies involving neovascularization of the cornea. Hopefully, a thorough understanding of these topics would propel the efforts to halt the detrimental effects of CNV.</p>
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